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Some patients find their maintenance dose is only one step below their therapeutic dose

As B12 is a water-soluble vitamin, it's generally considered safe (because any not used will be excreted via your urine), but even so you shouldn't take more than the recommended doses unless recommended to do so by your GP, as some studies have shown possible negative impacts of overdoing it

Whether these associations are causal, and the scope for intervention to improve health of older men with NAFLD, merit further evaluation

For EtOH-fed mice, the diet contained 2% v/v EtOH (10.8% total calories) in the first wk and the ethanol content increased weekly by 1% until reaching 5% v/v (27% total calorie)

High-dose NAC (1,200 mg/day) showed superior outcomes, improving lung volumes [Forced Vital Capacity (FVC), Residual Volume/ Total Lung Capacity (RV/TLC), Inspiratory Capacity (IC)] and exercise tolerance(30)