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In its complete response letter (CRL), the regulator said the application could not be approved based on data submitted to date and requested another Phase III study to further assess the safety and efficacy of the treatment, according to Lykos

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In addition, it has recently reported that both olezarsen for patients with severe hypertriglyceridemia and plozasiran for patients with persistent chylomicronemia have a significantly greater reduction in the TG level and in the incidence of acute pancreatitis than placebo 122,123