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Through NRF2-driven GSH synthesis, tumor cells are protected from oxidative stress, which contributes to chemotherapy resistance by reducing the cytotoxic effects of ROS generated during treatment
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Ubbink JB, van der Merwe A, Delport R, Allen RH, Stabler SP, Riezler R, and Vermaak WJH (1996)
Within the context of the urea cycle fumarate is generated by the actions of argininosuccinate lyase in the conversion of argininosuccinate to arginine
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